Rivaroxaban, sold under the brand name Xarelto, is a novel anticoagulant. The drug appeared on the market in 2011 and became a part of the treatment and prevention of thrombosis and its associated complications.
The medication is available in two doses of 10 and 20 mg and is increasingly vital in cardiological practice. Let’s learn more about the Xarelto application, its dosages, and its effect on patients.
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- Brand Names: Xarelto, Rivasmart;
- Active Ingredient: Rivaroxaban;
- Manufacturer: Bayer.
Xarelto and its drug substance Rivaroxaban
Rivaroxaban is an active ingredient based on which Xarelto was developed. The drug belongs to direct Factor Xa inhibitors that are essential in the process of blood clotting. Xarelto tablets help lower the risk of thromboembolic complications and prevent the formation of thrombi by slowing down blood clotting.
Unlike parenteral anticoagulants, Xarelto has the following benefits:
- Oral administration;
- Simple dosage regimen;
- No need to constantly/regularly monitor a patient’s state;
- A lower risk of interaction with food and drugs.
Rivaroxaban starts working in about one to three hours. The peak effect is seen three to four hours after administration.
Areas of Xarelto uses:
- Therapy, prevention, or lowering of the risk of recurrence of blood clots in vessels of the lungs or/and legs;
- Prevention of blood clots in vessels after surgery, for example, of the hip or knee joint prosthesis installation.
The drug can be used off-label to lower the risk of severe cardiovascular events and thromboembolic complications under other conditions.
Treatment regimens and Xarelto dosage
It is important to mention that a doctor can prescribe Xarelto proper dosage and treatment regimen, depending on a patient's history or the nature of their disorder. Patients must follow a doctor’s recommendations and monitor their state under medical supervision.
The standard regimen of Xarelto in adults:
- A typical daily dose - Xarelto 10 mg or 20 mg daily;
- Dosing schedule - 1 or 2 times per day.
For oral anticoagulants to be effective, one needs to be careful to the details and adhere to certain rules.
The dosage regimen can vary greatly depending on the treatment stage, medical condition, and individual characteristics of your body.
Recommendations on the use
Many oral anticoagulants need to be taken regularly at a particular time of day. Self-discipline is required to maintain a stable level of Rivaroxaban in the body. Follow the following tips and recommendations to get the maximum effect from the treatment:
- It is essential to take the drug at the same time every day;
- Missing even one dose may increase the risk of blood clotting and thromboembolic events;
- Swallow the whole tablet with a glass of water;
- You can grind the pill and mix it with water or apple sauce if needed;
- The medicine can be taken regardless of the meal.
Failure to follow these recommendations will decrease the effect of the drug, thus lowering its benefits to your body.
Before starting the treatment, ask your doctor what to do in case you miss a dosage. Recommendations may vary depending on the dosage regimen and a patient’s age.
Xarelto 10 mg and 20 mg doses are not suitable for people with certain diseases. Sometimes, these doses can be used only with caution. Please inform your doctor if you have at least one of the following conditions before starting the treatment with Xarelto:
- Dysfunction of the internal organs, including the kidney;
- Pathologies that may cause bleeding;
- Dysfunction of blood coagulation;
- Uncontrolled high blood pressure;
- Pregnancy, plans for pregnancy, or breastfeeding;
- Surgery for heart valve replacement.
You should be cautious when using anticoagulants to avoid an increased risk of injury. Avoid situations that may result in cuts, bruises, or abrasions, and be careful when practicing sports.
Use of Xarelto during pregnancy
This drug should not be taken during pregnancy or breastfeeding unless your doctor advises otherwise. Immediately inform your doctor if you get pregnant during the treatment.
Possible Xarelto side effects
In clinical trials, Xarelto tablets and the active ingredient Rivaroxaban were proven to be safe anticoagulants. However, they can cause adverse reactions, including the following:
- Dry mouth;
- Pain in the limbs;
- Muscle spasms;
- Abdominal pain.
Important! Medications that contain Rivaroxaban reduce the clotting of blood, which may result in more intensified hemorrhage even in case of minor injuries, including gum bleed, nosebleeds, gastrointestinal hemorrhage, etc.
Some patients may experience allergic reactions to oral anticoagulants. They may manifest as itching, skin rash, edema, shortness of breath, and other symptoms.
Xarelto: interaction with other drugs
Oral anticoagulants can interact with other drugs and lead to adverse reactions. Always inform your doctor that you take anticoagulants when starting another treatment.
The drugs and substances listed below may interact with Xarelto (Rivaroxaban):
- St. John's Wort;
- Platelet aggregation inhibitors;
- Nonsteroidal anti-inflammatory drugs.
Uncontrolled interactions may increase the risk of hemorrhage, cause side effects, or decrease the effectiveness of Xarelto. Always check whether new medications that you must take interact with anticoagulants you are already taking and follow your doctor’s recommendations.
Store Xarelto in a cool (from 15°C to 30°C) and dry place, away from sunlight. It is important to be sure you have enough tablets to continue the treatment course. Don’t leave the drug in the car during trips in hot weather; you’d better keep it in your bag. It is advised to store your medications in your hand luggage when traveling by plane.
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I won't write much. I'll just say it's a great drug. I've been taking it only five months after the operation (I have a thrombosis of the legs), and I have no complaints. The main thing is treating it on time.
Took it for 6 weeks after a serious operation on my knee. I waited for the worst, but it never happened. The drug deserves to be recommended.
Xarelto didn't work because my extremities were too painful after taking it. Switched to other pills.
Deep Vein Thrombosis, male, 66 years old. I've had no troubles with Xarelto. I've been taking medication for three and a half years and will have to continue taking it. The crucial thing is not to miss a dose.
It works rather well against blood clots in my lungs. But there is one significant side effect. My period lasts ten days now instead of 4. It is accompanied by unusually severe flow and clots. I'm trying to understand where it comes from now and whether Xarelto causes it.
Only 5 months ago, I discovered that I had a pulmonary embolism because I struggled to breathe. Doctors couldn't believe I was still alive or had gone so long without experiencing any signs of the disease. These pills literally saved my life. And continuing to do so.
I'm taking it against Afib, and it works. Sometimes, I have lower back discomfort and hip pain. Anyway, I think there is no need to stop taking the drug.
I'm taking the drug for deep vein thrombosis. Completely satisfied with the effect. I had a proximal (whole-leg) DVT 6 months ago, which caused severe edema and stiffness. 15 mg of Xarelto was recommended for one month, followed by 20 mg daily. I walked a lot when I could, and now the edema has wholly subsided.
I've been using Xarelto for five years to prevent blood clots in vessels of my lungs. No serious side effects. I just bleed less if I cut my skin.
The drug works well for me. Taking it to prevent the recurrence of blood clots in lung vessels. I've experienced no serious side effects from using Xarelto. However, it appears that since beginning the treatment, my skin has been itching constantly. There is no rash or strange look, only the itch. I'm curious whether this medication is to blame.
I was prescribed Xarelto for atrial fibrillation. Due to this drug, I avoided blood work and changes to my diet. So far, I had no side effects. I only noticed minor bleeding when brushing. That's it.
I was on Xarelto for 3 years (diagnosis - deep vein thrombosis). My treatment course ended a week ago. And I can share the results. I don't have a headache, lightheadedness, or a fuzzy head, and I have enough energy even in the evening. The drug made me feel different. I assumed it was simply becoming old. My vision also improved.
I've been taking Xarelto for seven months with no severe side effects. The only thing that perplexes me is that I almost don't bleed when cut. Doctors say it's OK.
This drug helped my vessels after my hip replacement surgery. But I felt very weak and suffered from dry mouth throughout the treatment.
This medication was prescribed to me by a cardiologist because, in my case, the risk of afib is high. Besides, I just turned 82. But I wasn't prepared for so many side effects. I faced an upset stomach, leg pain, and increased blood tension. Stopped taking it on my own.
After doctors put a prosthesis in my knee joint, I took this drug for five weeks. In general, the treatment went well, but I had to deal with muscle spasms and abdominal pain.
Unfortunately, the medication did not help me prevent a stroke. I must say that I am 85 years old and have survived several incidents earlier.
Well, Xarelto worked since I didn't have a stroke or blood cots, but I had many side effects. I'm also out of breath, and I've got tinnitus. I had never experienced this ear problem before using this medication. It's been one month since my first A Fib episode. The doctor said I may get off it now. I'm happy. Male, 69 years old.
I had a strange afib incident once. Male, 65 years old. There is no family history of cardiac disease. With a heart rate of 152, I was sent to the emergency room. I felt weak, hot, and simply awful. The heart returned to normal rhythm, and xarelto 30mg was prescribed as a precaution. Six days later, I saw the doctor. On this medicine, I felt safe. There were no side effects for me. Probably because of the short timing, though.
This med is quite OK. I had afib and ended up in the hospital. I use Xarelto as a blood thinner since having a stroke is far worse than any side effects. My father suffered seven strokes in the two years before his death at the age of 55. I occasionally have leg soreness after taking the medication, but I can deal with it.
Because of my recent operation, I've been on this medicine for 2 weeks. I don't know what effect this drug has on blood vessels, but it did make me suffer. My legs felt like they were on fire. Then my arms started to hurt. Stopped taking it and currently looking for alternatives with my doctor.
I've been on this medicine for five years because of my family history of stroke and the risk of thromboembolic complications. This drug effectively prevents strokes. Well, I should add that it's only my experience. But I guess you can get it.