Tretinoin Cream (Tretinoin)
4.80 / 317

Tretinoin Cream (Tretinoin)

4.80 / 317

Tretinoin Cream is intended for skin problems like acne, comedones, hyperpigmentation, and others. The cream helps reduce the signs of skin aging, including small wrinkles. Due to its thick consistency, Tretinoin cream 0.05 penetrates the skin deeply and intensifies the activity of its cells. This effect positively affects the health of the skin.

Moreover, Tretinoin cream uses differs from regular beauty products. The cream is used exclusively to solve specific problems on doctor's advice because it is a medical product. Improper use may lead to adverse reactions.

Tretinoin Cream

Drug Info

  • Brand Names: Retin-A Cream, Tretiheal Cream;
  • Active Ingredient: Tretinoin;
  • Manufacturer: Bausch Health Companies Inc, Healing Pharma.

Tretinoin Cream and its active substance Tretinoin

The active ingredient of Tretinoin Cream is Tretinoin - a vitamin A derivative. It is a first-generation retinoid originally developed for acne treatment. Tretinoin is also effective in combating photoaging. It penetrates the skin and interacts with specific cellular receptors, affecting DNA synthesis.

As a result, skin regeneration is accelerated; thus, pigmentation transfers to the top layer and is removed as the renewal process occurs. Tretinoin also reduces the production of sebum, decreasing inflammation and preventing the appearance of acne. The cream should be used regularly for several weeks to maximize the treatment's effect.

Indications for use

The cream is indicated for external application on the skin and is used for the following conditions:

  • Acne and comedones;
  • Hyperpigmentation.

Besides, Tretinoin Cream allows dealing with signs of aging, such as fine wrinkles and roughness of the skin.

Treatment regimens and dosages

The dosage and treatment regimen with Tretinoin Cream depends on the severity of your state. A doctor can recommend an individual plan of treatment to get the best results.

Usually, it is advised to apply a small amount of the cream to the affected area pointwise once a day, preferably before going to sleep. If your doctor prescribes another treatment regimen, follow it strictly.

Recommendations for use

To improve the results of Tretinoin Cream, follow the tips listed below:

  • Wash hands with soap;
  • Before applying the product, thoroughly clean the skin;
  • Do not apply the cream on top of skincare products.

Depending on the problem, the treatment duration may vary. A lasting result of acne treatment may be seen in two to three weeks of use. Hyperpigmentation usually takes three or four to six months.

Avoid contact of the cream with mucous membranes, including eyes, nose, mouth, etc. Also, do not apply Tretinoin Cream on skin areas with sunburn.

Missed Dose

If you didn’t apply the product in time, do it as soon as you remember. If you use the cream several times a day and the following application is soon, wait for it and apply the product according to the treatment scheme. Don’t increase the quantity of the product to catch up because it may lead to irritation.


Although Tretinoin Cream is applied to the skin and is not intended for oral administration, it may cause some adverse reactions. Please inform your doctor about all diseases you have. Take particular care in the following cases:

  • If your skin has high sensitivity;
  • If you had an allergy to Tretinoin or any other drugs or cosmetic products;
  • If you are allergic to fish;
  • If you had manifestations of eczema;
  • If you suffer from actinic keratosis (peeling of the skin);
  • If you have skin cancer.

Tretinoin Cream can increase the sensitivity of the skin to UV rays. Use sunscreen and avoid prolonged exposure to direct sunlight during the treatment.

It is recommended to avoid any manipulations that can injure the skin, including depilation, peelings, etc. Do not apply Tretinoin Cream right after the influence of products containing salicylic acid, serum, or resorcinol on your skin.

Use of Tretinoin Cream during pregnancy

There is no evidence that using the drug during pregnancy may cause potential harm to the fetus. However, the reaction depends on your individual characteristics. Before using Tretinoin Cream, inform your doctor about your pregnancy or plans for pregnancy to avoid possible side effects.

Also, there have been no trials to study the effect of the drug on breast milk and the dangers of using it while breastfeeding. Inform your doctor before the start of the treatment if you are breastfeeding.

Possible side effects

Since Tretinoin Cream is applied to the skin, most side effects manifest as skin symptoms. Adverse reactions are rare and short-term, but in some cases, they can cause significant discomfort. The most common side effects are the following:

  • A warm sensation and slight prickling in the area of application;
  • A change in skin color;
  • Redness;
  • Peeling;
  • Increased acne;
  • Blisters or crusts on the skin;
  • Dry skin.

Sometimes, side effects may be more severe:

  • Urticaria;
  • Pain and discomfort in the area of application.

The following side effects in the form of severe allergic reactions to the drug are infrequent:

  • Swelling of the throat, tongue, and face;
  • Difficulty breathing;
  • Dizziness.

If you experience severe adverse reactions, contact the nearest emergency department immediately.

The list of side effects is not complete. Other adverse reactions may occur when using Tretinoin Cream. If you experience the intensification of side effects or worsening of your well-being, contact your doctor.

Tretinoin Cream: interaction with other drugs

The medication can interact with other drugs for external application. Moreover, administration of some oral drugs can cause side effects when using Tretinoin Cream, including the following:

  • Tetracyclines;
  • Antihistamines;
  • Diuretics, etc.

It is an incomplete list of possible drug interactions. Tell your doctor about all the drugs you take. Read the instructions to the drug or contact your pharmacist to learn more about drug interactions.


Store Tretinoin Cream at temperatures below 25 °C in a place protected from light. Keep out of reach of children and pets. The drug can not be stored in the refrigerator. Do not use this product if it has expired or is damaged.

The best offer for Tretinoin Cream online on the market

Our pharmacy offers Tretinoin Cream at the best price compared to our competitors. We guarantee the effectiveness and safety of a drug and compliance with EU standards. We work throughout Europe and will ship your order from the nearest warehouse to your door. Moreover, we ensure 100% privacy - every order is shipped in non-transparent packaging. Using our services, you get the following benefits:

  • Delivery within a few days;
  • 24/7 Customer Support;
  • User-friendly system of payment orders (VISA, MasterCard, American Express, or bank transfer).

By buying in our pharmacy, you can save time and start the treatment as soon as possible. You can contact our experts, who will answer all your questions if you need help.

How to buy Tretinoin Cream online

You can buy Tretinoin cream online on our website. We’ve developed a simple and convenient order form for our clients. It will take a few minutes to place an order; fill in the appropriate fields to complete it:

  • Name of the drug;
  • Dosing;
  • Quantity;
  • Shipping address.

We will prepare your order as soon as possible and ship it to the indicated address. If you have any issues while placing an order, contact our customer service representatives, who are available 24/7 and are ready to assist. Buy now to get your order in a few days.

  • Julia Messer

    This cream really works for acne. But it takes patience to use it. I had redness and peeling in the middle of my treatment. And my skin looked terrible before it looked healthy. Now, after 5 months, I'm finally happy with the results. My tip is to use it only before bed and apply a light cleanser or simple water in the morning. Talk with your doctor about the best moisturizer for your skin. You will need it.

  • Lyla Roche

    I had cystic acne that appeared mostly around my chin and occasionally on my forehead. I've seen several doctors and tried numerous treatments. But nothing helped like Tretnoin. This med deserves the highest praise. It made me feel and look good.

  • Adeline Darling

    My skin stopped being pure at the age of 18. Only birth control pills helped a little bit from acne, and only for a while. I tried many creams and ointments. But the acne always came back again. Tretinoin turned out to be the best remedy I used to treat acne. After six weeks, the skin became much clearer, and even the scars seemed to fade. Highly recommend this cream. It works.

  • Eva Corley

    Tretiheal 20g 0.025% was quite beneficial to me. It took two months to notice any benefits. The skin tone improved first, followed by lesser and smaller breakouts. After 4 months, I couldn't recognize my reflection in the mirror – there were no lumps and my skin!! It's just a miracle.

  • Olivia Munson

    The first pigment spots on my face appeared after my pregnancy. Then, I just watched them grow larger. I felt helpless, as no cream helped me. I realized I needed professional advice and went to the doctor who prescribed me Tretiheal 20g 0.05%. I have used it every two nights for three months now. I already see the first results. There is a small amount of flaking, which is normal. And the skin that remains looks fantastic. I hope I will get rid of all the spots in the end.

  • Jason Lay

    Unfortunately, this cream didn't suit me. I had severe flaking and redness. It all looked terrible to me, and I stopped using it. The doctor told me I had to wait and go through that phase, but I couldn't. It's not for me.

  • Claire Prescott

    Firstly, I started to use it to get rid of adult acne. Then, I applied it to make my skin look younger. So far, my story with Retin-A Cream has lasted for 25 years. People can never guess my actual age. I look at least 10 years younger. What about side effects? Well, I had peeling and redness phases at the beginning of my way, but that didn't stop me. Healthy skin without wrinkles is worth it.

  • Mila Dumas

    I'm 40 years old, and I recently started using this cream to rejuvenate the skin and remove age spots. I can already see changes after two months. My skin became younger and brighter, and fine lines have become less evident. I'm really delighted!

  • Tom Currie

    My experience with this med was great. After 3 months of use, my skin became completely clean. I was terribly insecure due to acne and avoided people because of my skin problems. Now I finally feel free and OK with my looks.

  • Madison Stringer

    Started to use it four months ago. The cream helps me to get rid of deep, painful cysts. So far, I'm over the moon with happiness. It's been two weeks since I've had no new pimples. To be continued…

  • Jolie Flood

    I'm using Tretinoin cream for photoaging of the skin. I started to use it more than 20 years ago, and I never regretted this decision. I'm 60 years old and have a porcelain-like skin texture. People are constantly asking me about my skincare routine. I've never had botox or something like that. However, I almost have no wrinkles. Retin-A deserves all of the credit.

  • Tala Okeefe

    I've been dealing with acne for quite some time. I decided to try Tretnon cause my friend with similar skin issues had great results on it. After 4 months, I can say this cream didn't work well on me. It causes dryness and redness, and acne is still there. So it's not for me, or I used it wrong, idk.

  • Brielle Platt

    I read reviews before using this cream and knew all the downsides. The first and second weeks were rather peaceful. The purging began in week three, and it was dreadful! I was almost forced to give up, but I persisted. The purge lasted until week eight. After that, my skin became healthier with every day. So far, I'm satisfied with the results!! Recommend it if you are ready to go through the purging phase.

  • Sage Mott

    My diagnosis is post-inflammatory hyperpigmentation. Things were so bad that I couldn't leave the house without a ton of foundation on my face. Tretiheal 20 g 0.05% helped me lighten my skin. It took six months. I feel like a different person now. The skin began to exfoliate around the middle of the treatment course, but I tolerated this side effect to get the skin of my dreams.

  • Paige Christiansen

    I am 35 years old. My struggle with problematic skin began 20 years ago, but until now, I had no positive results. I have tried an enormous number of different cosmetics and procedures for acne. Now, my list also includes Retin-A Cream. I used it for five weeks and noticed only a slight effect. The skin became a little more even.

  • Ava Penn

    About my skin: combined with acne and enlarged pores. The cosmetologist prescribed me this cream to get rid of acne. But I also noticed the anti-age effect! I have been using the cream for 4 months, and I am not going to stop. There is only one drawback. My favorite peelings should be forgotten for the whole treatment course!

  • Abbey Cornish

    Retin-A cream helped me forget about the terrible acne (cystic type). The skin is completely cleansed of acne. There are only traces of them now. Sometimes, there are inflammations, but they are tiny and pass quickly.

  • Rachel Rey

    For the first time, I started thinking about acne treatment after my first semester of college. Stress, poor nutrition, and sleep deprivation have influenced my skin badly. My face was covered with large subcutaneous pimples. Ordinary cosmetics could not cope. So, the beautician prescribed me Tretinoin Cream. In the first week, I used the cream 2 times; in the second 4, and only in the third week did I begin to use the cream every day. After three months, my skin was clean, and I stopped using the product. Since that time, I have had no problems with acne. Have changed my diet to a healthier one, though.

  • Rick Hefner

    Used the cream to treat acne. Achieved the desired result after 4 months of daily use. Remember that the skin should be dry and clean at the time of application! Water increases retinol penetration and can cause an aggressive reaction. I made that mistake once before, and I got irritation.

  • Meryl Strunk

    I used this product for hyperpigmentation. It took a lot of patience to see the result. The spots began to light up after 5 months! But my effort was worth it. My personal recommendation: don't put too much cream on! One pea is enough. In this case, more doesn't mean better.

  • Ralph Sprouse

    As a teenager, I faced the problem of cystic acne. Diet and healthy lifestyle did not help; antibiotics didn't change much either. These were temporary, ineffective measures. Pimples appeared again after I stopped taking the pills. I tried Retin-A Cream only 2 years ago and regret that I did not use this cream before. The cream gives a long-term and quite durable effect.

  • Lana Heinz

    My beautician told me to put this cream in my daily skincare routine to deal with fine wrinkles and coarsening of the skin. It is too early to discuss the results, but I noticed an excellent moisturizing effect.

  • Sandra Eagle

    I bought this cream after a visit to my cosmetologist. The cream is not fat but viscous. It is rather difficult to distribute it on the skin, as it is almost immediately absorbed. So far, I have used it for two weeks with breaks (as recommended by the doctor). New pimples do not appear, and old ones heal faster.

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