Nolvadex (Tamoxifen)
4.79 / 267

Nolvadex (Tamoxifen)

4.79 / 267

Nolvadex is a modern drug mainly used to prevent the risk of breast cancer and to treat the disease. Nolvadex is an anti-estrogenic agent, inhibiting estrogen and suppressing tumor growth.

You can also use the medication to treat other conditions. Moreover, Nolvadex PCT (Post Cycle Therapy), which makes it possible to neutralize the effects of steroids, is widely used in bodybuilding.

Nolvadex Generic

Drug Info

  • Brand Names: Nolvadex, Tamoxican, Tamilong;
  • Active Ingredient: Tamoxifen Citrate;
  • Manufacturer: AstraZeneca.

Nolvadex and its active substance Tamoxifen

The active ingredient of Nolvadex is Tamoxifen. It is an estrogen antagonist, also having a selective stimulating effect on estrogen receptors. In the cells of the mammary gland, it plays the role of an anti-estrogen, and in the cells of other tissues (bones, uterus), Tamoxifen acts as an estrogen.

The effect of the drug depends on the purpose of its use. Tamoxifen suppresses tumor growth when used to treat breast cancer. After you take the pill, the drug substance gets into the blood and blocks estrogen receptors in the mammary gland, preventing estrogen from reaching cancer cells.

Indications for use

Nolvadex is mainly used for the treatment of estrogen-dependent diseases. The main indications for using the drug are as follows:

  • Breast cancer;
  • Primary prevention of breast cancer in women at high and moderate risk;
  • Anovulatory infertility.

Using Nolvadex in bodybuilding is common to reduce estrogen and prevent gynecomastia in men.

Treatment regimens and dosages

The drug is available in dosages of 10 mg and 20 mg. Depending on the disease and individual characteristics, the doctor prescribes a dosage and treatment regimen. The following dosages and treatment regimens are usually used:

  • For breast cancer, the standard recommended daily dosage is Nolvadex 20 mg. The doctor determines the treatment duration based on the disease's severity and other factors.
  • Nolvadex 20 mg is also used for the primary prevention of breast cancer, with a treatment duration of about 5 years.
  • For anovulatory infertility, the starting dose is Nolvadex 20 mg on the cycle's second, third, fourth, and fifth days. Then, you can increase the daily dosage to 40 mg if required.

You can take the drug once or twice a day. The doctor may decrease or increase the daily dosage if appropriate. Follow the doctor's recommendations, and don't change the dosage on your own.

Older people can use the same dosages, as there is no evidence that their response to Tamoxifen differs from that of younger people.

Nolvadex may affect thyroid function test results. So, inform them about taking the drug before the test.

Recommendations for use

Nolvadex is available as an oral tablets. To get the maximum effect from the medication, follow these rules:

  • Take the drug at the same time;
  • Don't crush the pill before use;
  • Take the tablet with plenty of water;
  • If you take several tablets at a time, take each of them with water.
  • Take the drug before or after meals.

During treatment, you should minimize or stop drinking alcohol, as it may increase the side effects of Tamoxifen and reduce the effectiveness of treatment. If you can't completely give up alcohol, ask the doctor to determine your acceptable limit.

Grapefruits (and grapefruit juice) and tangerines can also lower the effectiveness of the medicine.

Missed Dose

Follow the treatment regimen, and don't miss doses. If you miss a dose, your next action depends on how many times a day you take the drug:

  • If you take the medication once a day and if less than 12 hours have passed since the last dose, take the prescribed single dose of Nolvadex. If more than 12 hours have passed, skip the dose and wait until your next dose.
  • If you take the drug twice a day, take the missed dose as soon as you remember. If it is near time for your next dose, take only that dose. Then, return to your regular Nolvadex treatment regimen. Don't take a double or extra dose.


Before treatment, inform the doctor about all your diseases. In some cases, a doctor should control the treatment. These cases include:

  • Drug allergies;
  • Deep vein thrombosis;
  • Pulmonary embolism;
  • Heart stroke;
  • High cholesterol;
  • Diabetes;
  • Hypertension;
  • Cataract;
  • Liver disease.

Individual intolerance, pregnancy, and breastfeeding are among the medicine contraindications.

Use of Nolvadex during pregnancy

Pregnant women shouldn't use the drug due to the high risk to the fetus. Moreover, during treatment, you should avoid pregnancy using proven contraception methods. If you get pregnant while using Nolvadex, stop taking the drug immediately and inform the doctor.

Currently, there is no data on whether Tamoxifen gets into breast milk. So, due to the possible risk to the child, you shouldn't also use the drug during breastfeeding.

Nolvadex in bodybuilding

In bodybuilding, Nolvadex PCT (Post Cycle Therapy) is an effective way to avoid the effects of steroids. The drug also helps reduce estrogen levels and improve training results.

You can also use Nolvadex for gyno (gynecomastia) in men. Anabolic steroids may cause gynecomastia. So, after taking these drugs, you can use Nolvadex to prevent this medical condition. Using Nolvadex in bodybuilding has these benefits:

  • Restoring hormonal levels;
  • Preventing gynecomastia;
  • Preventing other side effects of steroid drugs;
  • Improving skin and hair condition;
  • Decreasing blood pressure;
  • Reducing cholesterol.

Possible Nolvadex side effects

Usually, people tolerate the drug well, and possible side effects are mild and go away with time. The most common side effects are as follows:

  • Headache;
  • Nausea;
  • Leg cramps;
  • Flushes of blood to the face;
  • Hair thinning;
  • Muscle pain.

You may rarely have severe side effects, such as:

  • Blurred vision or other eyesight changes;
  • Pain in the eyes;
  • Bruising or bleeding;
  • Nausea, vomiting, loss of appetite, yellow whites of the eyes;
  • Severe allergic reactions (difficulty breathing, rash, swelling).

If side effects increase or you experience severe side effects during treatment, see the doctor immediately.

Nolvadex: interaction with other drugs

Nolvadex may interact with other medications. So, before treatment, inform the doctor about all the medicines you take. Adverse effects are possible when combining it with these drugs:

  • Anticoagulants or blood thinners;
  • Estrogen-containing drugs;
  • Hormonal contraceptives;
  • SSRI antidepressants;
  • Anticonvulsants;
  • St. John's wort-based drugs.

It is not a complete list of drug interactions. For more information about possible interactions, check with a doctor or pharmacist and read the package insert for the drug.


Store Nolvadex at room temperature 20 - 25°С in a dark place out of the reach of children and animals. Don't use the drug if the expiration date has passed or the packaging is damaged.

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  • Vanessa Evans

    I always controlled my condition because my maternal relatives had breast cancer. I took the drug strictly on the recommendations of the doctor. Flushes, bone pain, and weight gain slightly spoiled my life. But that's nothing compared to not having cancer due to taking Nolvadex.

  • Jenna Reynolds

    I took the drug because of the diagnosis - malignancy in the breast. At first, I was afraid that it was a hormonal drug. But the fears were in vain. From the first weeks of treatment, I felt a surge of energy. It's been a few months since I started treatment. And I'm looking forward to positive dynamics.

  • Forrest Perry

    I took steroids for a long time, which led to the risk of gynecomastia. My doctor prescribed me a small dose of Nolvadex (10 mg). So far, I have seen positive changes and hope I will get even better soon. The med distorted my test results on the thyroid function a little bit. It is a good thing I knew about this drug's features.

  • Piper Roberts

    The medication helps me feel better and continue to be active. But I had to give up my favorite tangerines. Turns out they're not compatible with the drug.

  • Dorothy Saunders

    So far, I have experienced only preventive benefits – more energy and overall well-being. The final results are very far… It's too early to tell cause I must take pills for a few years.

  • Maggie Thomson

    At first, I was prescribed a dosage of 20 mg for breast cancer prevention. But after a few months after the treatment began, I plunged into a terrible depression because of the drug. In addition, I was tormented by flushes and joint pains. Then, my doctor advised me to lower the dose to 10 mg. My body tolerates lower dosages much better.

  • Tess Wright

    Five months ago, I was diagnosed with stage 1 breast cancer. Since then, I've been taking Nolvadex, and I'm also undergoing chemotherapy. Now, I'm out of my period, I've lost the desire to have sex, and I have constant back pain. I hope that with time, at least some of these side effects will disappear…

  • Rosie Long

    I was prescribed five years of pills after breast surgery. Now, I am 49, and I have taken the medication for the second year. I can share my life hacks to deal with side effects. If possible, be active because the drug promotes weight gain. But if you do exercise, it won't be a problem. No alcohol and greasy food, just a healthy diet. Also, I wear clothes made of natural fabrics, preferably cardigans with T-shirts to put off the top layer in case of hot flashes. I wish everyone a recovery. Stay strong.

  • Faith Patel

    I'm surprised when I read about many side effects some people have. I guess I'm lucky because I haven't had any complaints in five years of taking the drug. Except that it was harder to fall asleep.

  • Hope Bailey

    I already took this medication about a year ago. But the doctor gave it to me again for another 5 years, for breast cancer prevention. This time, it is different. The side effects are much worse, and I doubt I'll be able to finish the treatment

  • Paige Reed

    My night sweating was so intense that I had to change pillows and mattresses. I also have joint pains. It's a pity my diagnosis doesn't have many alternatives. I'll probably have to endure.

  • Annie Ortiz

    At the beginning of the therapy, I took Nolvadex 20 mg. But the joint pains were so severe that I could not sleep without painkillers. After 3 months, the doctor reduced the dose to 10 mg. Well, that's a whole other thing! The pain is almost completely gone. So, the treatment continues.

  • Lena White

    I take the drug for 5 months. So far, I noticed no side effects. I feel calm and full of energy.

  • Ivy Roy

    This is a drug for people with strong will. I know why I take these pills and understand that they cure me of cancer. It is important to remember whenever you experience hot flashes, mood swings, and joint pains.

  • Georgia Morin

    I've been on Nolvadex after chemo. And all in all, I have no complaints. I'm happy I don't have cancer anymore and thankful that these pills keep me that way

  • Evelyn Allen

    This drug influenced my mental state massively. My mood swings are terrible, and I often feel depressed. Consider stopping the treatment because I don't have cancer and took it only for disease prevention

  • Brooks King

    Taking it for half a year for breast cancer prevention. And so far, I'm satisfied with the results I see and feel. I've learned how to deal with a few side effects I constantly have. Staying hydrated helps with an upset stomach. And I go to bed 2 hours after I take the pill. It helps me avoid sleepiness.

  • Edith Gomez

    I've been on Nolvadex for 4 months and happy I tried it. At first, I was terrified of the side effects I saw in other people's reviews. But I haven't experienced any of that.

  • Jane Turner

    I've been using this med to prevent breast cancer recurrence for 5 years. Several times, I honestly wanted to stop my treatment. The side effects were so severe that I struggled to function. My biggest problems were mood swings and bone discomfort. I believe living with the adverse effects would be simpler if my doctor told me more about them. That is why I wrote my review for the benefit of others.

  • Scarlett Murphy

    I started Nolvadex a month ago, and since then, I wake up at night with night sweats and sleeplessness. Also, I found that I was more hungry and seeking junk food, which led me to gain about 6 pounds. However, I can cope with these adverse effects because I know the medications are helping my condition.

  • Lucy O'Brien

    I had a tiny tumor in my right breast. Fortunately, early discovery at the age of 39 made my journey much easier. After 4 months of taking the pills, I've only had one adverse effect - the rare hot flash. So far, I've been quite fortunate. I hope the cancer never returns.

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